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You can cast another spell from among the milled cards using the permission granted by Locke's last ability

Annihilator helps a lot too, of course, but its mostly just a big old threat

For example, if you control The Ozolith ("Whenever a creature you control leaves the battlefield, if it had counters on it, put those counters on The Ozolith.") when Sin's last ability resolves, you'll put the appropriate number of each kind of counter onto both The Ozolith and the target creature

She's also legendary for Commander purposes, but do note that her ability only works once per damage dealt no matter how many punched face with that "or more" language there